Trimethobenzamide hydrochloride( Ro 2-9578 | Tribenzagan Hydrochloride )

Catalog No. M19813 CAS No. 554-92-7

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Product Name

Trimethobenzamide hydrochloride
Note

Research use only, not for human use.
Brief Description

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
Description

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.(In Vitro):Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center.(In Vivo):The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration.
In Vitro

Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center.
In Vivo

The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration.
Synonyms

Ro 2-9578 | Tribenzagan Hydrochloride
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

D2
Research Area

Others
Indication

Nausea and vomiting

1.Smith HS et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.

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